Nutrient Therapy Vitamin B12 Injections

B12 Cheshire Wellness Clinic

Vitamin B12 is an essential nutrient that is involved in many crucial functions in the body, and B12 injections are a great way to increase your levels. Do you know if you have enough B12? Consequences of B12 deficiency range from fatigue, vision loss and constipation to neurological problems, psychiatric problems and certain types of anemia.

Vitamin B12 is found almost exclusively in animal foods, so long-term vegans and vegetarians are at an elevated risk of deficiency. In addition, absorption of this nutrient from food is a somewhat complex process and may be impaired in some people.

What are the available B12 injections?

B12 also known as cobalamin, vitamin B12 is an essential water-soluble nutrient that is part of the B complex of vitamins.

B12 is more complex than the other B vitamins.

The name cobalamin comes from the fact that this vitamin contains cobalt.

B12 is the only B vitamin which contains this element.

Different forms of cobalamin are available in supplement form,cyanocobalamin, methylcobalamin, hydroxycobalamin, and adenoxylcobalamin.

Different forms of B12 injections are appropriate depending on an individual’s methylation status.

Which ones do we use?

Methylcobalamin is the active form of B12, which is easily absorbed and passes the blood brain barrier, making it an effective treatment for depression and mental fatigue.

Cyanocobalamin must be converted to hydroxycobalamin, which is then converted to methylcobalamin. Many people have inadequate enzymes to convert cyano and hydroxycobalamin to the active form.

Therefore, injections to avoid are cyanocobalamin because of trace amounts of cyanide present in cyanocobalamin.

There is only one type of vitamin B12 injection available in the UK, known as hydroxocobalamin.

Can anyone get B12 shots?

No, only if you have a true deficiency. If you do not already receive the B12 injection, you must be tested for a deficiency before we can treat you. This is to make sure that you are suitable for the injection.

To be treated at Cheshire Wellness Clinic, we do need to check your levels of Vitamin B12, Folate and Methylmalonic acid (MMA to understand the cause of your deficiency and ensure that you receive the right treatment.

What causes B12 deficiency?

The main causes of B12 deficiency include inadequate dietary intake and malabsorption issues.

Vitamin B12 deficiency may occur if you have certain conditions, such as:

  • Pernicious anemia, which makes it hard for your body to absorb vitamin B12 (characterized by a lack of intrinsic factor – individuals cannot properly absorb vitamin B12 in the gastrointestinal tract)
  • Atrophic gastritis or inadequate production of stomach acid (occurs in 10-30% of older adults!)
  • Helicobacter pylori infection in the stomach
  • Surgery that removed part of your stomach or small intestine including bariatric surgery (Surgical procedures in the gastrointestinal tract, such as weight loss surgery often result in a loss of cells that secrete hydrochloric acid and intrinsic factor)
  • Small intestinal bacterial overgrowth (SIBO)
  • Parasite infections, such as giardia, tapeworm
  • MTHFR gene mutations
  • Chronic pancreatitis
  • Heavy alcohol use or advanced liver disease
  • Autoimmune conditions, such as Grave’s disease, Lupus
  • Malnutrition or eating disorders
  • Long term use of medications
    • Proton pump inhibitors
    • H2 blockers
    • Metformin
    • Certain antibiotics

B12’s role in your genetic pathways and as a methyl donor

Vitamin B12 has an important role in some of your key genetic pathways.  B12 needs to be converted into its active form, methylcobalamin to be usable in the cells of your body.  This process takes place through the MTRR enzyme. Up to 30% of the population has a down-regulated MTRR SNP (single-nucleotide polymorphism) potentially impairing this vital process.

Methylcobalamin intersects with methylfolate at the MTR enzyme, where both nutrients are required to stimulate the methionine pathway.

The methionine pathway is one of the most crucial in the body as it involves the production of SAMe, the body’s major methyl donor.  Methylation and the methionine pathway is upstream of many functions in the body, including detoxification and the clearance of hormone and neurotransmitters.

MTHFR is an enzyme that participates in your body’s folate and methylation cycle. It is needed to produce methylfolate, which recycles homocysteine, produces SAMe and recycles biopterin, all extremely important nutrients in the body.

Testing for B2 deficiency

  1. Serum B12-This test determines how well you are able to process, methylate and functionally use B12.
  2. Methylmalonic acid(MMA)-This measures the B12 stored in tissues, which makes it more specific to B12 deficiency than the other blood tests
  3. Nutrigenomics (MTHFR genetic test)The more mutations one has to this gene, the more they require B12, folate, and B6 for their detoxification pathways and body to function optimally. It’s estimated that those with one mutation decrease their ability to methylate by 30% and those with two mutations decrease their ability to methylate by 70%, making it virtually impossible get adequate B12 from diet alone


What if I`m on medication?

It is essential that you inform your doctor prior to your injection of any medications.

What testing can I get to see if I`m suitable for this?

We recommend the Folate, Vitamin B12 & Methylmalonate test -£145. This test measures levels of Folate, Vitamin B12 and Methylmalonate in blood.

DNA Methylation genes which is a saliva test -£85

How often can you take B12 Injections?

The frequency of taking Vitamin B12 injections   will change depending on the cause for actually opting for B12 injections and the tested B12levels before starting the treatment.

Your vitamin B12 levels can be accurately checked by a simple blood test, which will detemine if you are a suitable candidate for B12 shots.


Here at Cheshire Wellness Clinic we could  just address the low B12 level alone, but it does not provide us with some unanswered questions such as

Why are your deficient in the first place?

Cheshire Wellness Clinic is an integrative approach to skin health, combining whole foods based nutrition and lifestyle practices with natural skin care products and non ­invasive aesthetic treatments.



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